多面的人类抗原R (HuR):肝脏新陈代谢和MASLD的关键参与者
Natalie Eppler1, Elizabeth Jones1, Forkan Ahamed1
1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, MS 1018, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Livers
|August 14, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题. 本综述强调了人类抗原R (HuR) 蛋白在肝脏健康和MASLD进展中的关键作用.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 分子生物学分子生物学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球25-30%的成年人,需要新的治疗方法.
- MASLD可以发展为与代谢功能障碍相关的脂肪肝炎 (MASH),增加肝硬化和肝癌的风险.
- 关键的代谢途径在MASLD中失调,但进展的分子驱动因素尚未完全理解.
研究的目的:
- 审查mRNA结合蛋白的人类抗原R (HuR) 在MASLD中的作用.
- 探索HuR在代谢途径和肝脏平衡的转录后调节中的功能.
- 讨论HuR在MASLD进展和并发性疾病中的参与.
主要方法:
- 这是一个叙事评论,总结了主要文献和最近的评论.
- 专注于HuR在转录后调节中的作用.
- 检查了将HuR与肝脏平衡和代谢压力联系在一起的证据.
主要成果:
- 在调节营养代谢,细胞存活和应激反应方面,HuR起着至关重要的作用.
- HuR对于维持肝脏平衡至关重要,特别是在代谢压力下.
- 肝细胞特异性HuR枯竭加剧了MASLD的严重程度.
- 肝外组织中的HuR失调会导致肥胖和糖尿病等并发性疾病的肝功能障碍.
结论:
- HuR是肝脏平衡和MASLD进展的关键调节者.
- 了解HR监管网络可能会导致针对MASLD的向疗法.
- 在并发性疾病中HuR的作用强调了它在代谢健康中的系统重要性.
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