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腹部肥胖,2型糖尿病,禁食胰岛素和宫盘疾病,骨质疏松症和类风湿关节炎之间的因果关系:孟德尔的随机化研究

Hanming Tang¹, Jie Zhao², Xuexu Yan¹

¹College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250014, People's Republic of China.

Journal of multidisciplinary healthcare

|August 14, 2025

概括

诸如腰比和2型糖尿病等代谢因素增加了类风湿关节炎的风险. 2型糖尿病和禁食胰岛素与宫椎间盘疾病有关,而2型糖尿病可以预防骨质疏松症.

科学领域:

遗传学和精准医学遗传学和精准医学
代谢健康代谢健康
整形外科整形外科整形外科

背景情况:

之前的研究表明,骨科疾病和代谢障碍之间存在联系,例如2型糖尿病 (T2D),胰岛素抵抗和腹部肥胖.
这些疾病之间的因果关系尚不清楚.
这项研究使用门德尔的随机化 (MR) 来探索因果关系.

研究的目的:

调查腹部肥胖,T2D和空腹胰岛素 (FI) 对宫椎间盘疾病,骨质疏松症 (OP) 和类风湿性关节炎 (RA) 的因果关系.
澄清关键代谢因素与常见的骨科疾病之间的相互作用.

主要方法:

使用孟德尔随机化 (MR) 与全基因组关联研究 (GWAS) 的暴露数据 (腰比 [WHR],体重指数 [BMI],FI,T2D) 和FinnGen数据的结果 (宫椎间盘疾病,OP,RA).
采用单变量 (UVMR) 和多变量 (MVMR) MR分析,包括反变量加权 (IVW),MR-Egger和加权中位数方法.
通过使用科克兰的Q测试,MR-Egger拦截和留出一个方法进行了灵敏度分析.

主要成果:

基因预测的WHR是宫椎间盘疾病和RA的风险因素.
FI与宫椎间盘疾病的风险增加有关.
T2D增加了RA风险,但显示出对OP的保护作用. MVMR证实了这些协会和WHR在RA中的作用.
在MVMR中,FI与宫椎间盘疾病有积极的关联.

结论:

基因预测的WHR和T2D与RA风险增加有关.
T2D和FI增加了宫椎间盘疾病的风险.
T2D证明了对OP的保护作用.
研究结果提供了对代谢和骨科相互作用的见解,有助于临床决策和疾病管理.

关键词:

门德尔的随机化腹部肥胖症腹部肥胖症宫椎盘疾病宫椎盘疾病禁食胰岛素禁食胰岛素骨质疏松症是一种骨质疏松症.类风湿性关节炎类风湿性关节炎 2 型糖尿病 2 型糖尿病

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