在精神分裂症中,突深度的改变和相关的功能连接与听觉语言幻觉的改变
Zhenru Guo1, Zimo Zhou1, Shuai Wang1
1Department of General Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.
Frontiers in psychiatry
|August 14, 2025
概括
精神分裂症患者有听觉语言幻觉显示大脑深度和功能连接的改变,特别是在默认模式和视觉网络. 这些变化可能表明早期的神经发育问题,并作为早期诊断的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 精神分裂症的听觉语言幻觉 (AVH) 与大脑异常有关.
- 在AVH中,硫深度和功能连接的表征仍然不清楚.
研究的目的:
- 为了调查精神分裂症患者和没有AVH的深度改变和功能连接.
- 探索这些神经成像发现与临床症状之间的关联.
主要方法:
- 招募了38名患有AVH和31名没有AVH的精神分裂症患者.
- 利用磁共振成像 (MRI) 进行深度分析和基于种子的功能连接.
- 通过使用标准化尺度评估临床症状.
主要成果:
- 在AVH患者中,左半球深度增加,右半球深度减少.
- 在AVH患者中观察到广泛的功能性连接性减弱,特别涉及高级额头和角.
- 突深度增加与负面症状和一般精神病理学有关.
结论:
- 突深度和功能连接异常在患有AVH的精神分裂症中突出表现.
- 研究结果表明,早期的神经发育障碍涉及默认模式和视觉网络.
- 突深度可以作为早期精神分裂症诊断的有希望的生物标志物.
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