向瘤血管内皮细胞用于肝细胞癌治疗
1Bond Life Sciences Center, University of Missouri, Columbia, MO 65212, United States.
World journal of gastroenterology
|August 14, 2025
概括
肝细胞癌 (HCC) 的进展受到瘤血管内皮细胞 (VEC) 的影响. 阿帕提尼布通过PI3K/AKT/PFKFB3路径向VEC糖解,提供了对抗肝癌的潜在策略.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 分子信号传输的方法
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 瘤血管内皮细胞 (VEC) 在HCC进展中至关重要,促进血管生成,增殖,迁移和治疗耐药性.
- VECs通过招募髓状细胞衍生的抑制细胞和损害细胞毒性CD8 T细胞反应来影响瘤微环境.
更多相关视频
09:49Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
Published on: December 2, 2013
10.4K
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
9.0K
相关概念视频
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
01:27Tumor Immunotherapy
660
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
660