三维动态光学连贯断层扫描用于评估乳腺瘤边缘
Joel A Bellesini1,2, Ken Y Foo1,3, Jiayue Li1,3
1BRITElab, Harry Perkins Institute of Medical Research, Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA 6009, Australia.
Biomedical optics express
|August 14, 2025
概括
动态光学一致性断层扫描 (d-OCT) 提高了乳腺瘤边缘评估. 这种技术可以改善恶性和良性组织之间的对比度,从而有可能降低乳房保护手术中的再切割率.
科学领域:
- 生物医学光学 生物医学光学
- 手术瘤学手术瘤学
- 医疗成像医学成像
背景情况:
- 术内边缘评估对于乳房保护手术 (BCS) 至关重要,以最大限度地降低再切割率.
- 光学一致性断层扫描 (OCT) 提供非侵入性的3D组织成像,但通常缺乏乳腺组织的对比度.
- 动态OCT (d-OCT) 利用时间信号变异来增强对比度,在乳腺瘤边缘评估中应用有限.
研究的目的:
- 调查动态OCT (d-OCT) 对改善乳腺瘤边缘的手术内评估的实用性.
- 评估各种d-OCT可视化方法,以获得恶性和良性乳腺组织之间的最佳对比.
- 评估d-OCT在减少乳房保护手术期间重新切割率方面的潜力.
主要方法:
- 从十个人类乳腺切除标本和三个BCS宽局部切除处获得3Dd-OCT图像.
- 进行共同注册的组织学,以验证d-OCT发现.
- 探索多种d-OCT可视化技术,包括里埃分析和色彩空间转换 (RGB,HSV) 和相差.
主要成果:
- 使用d-OCT与标准OCT强度相比,恶性 (IDC,DCIS,ILC,LCIS) 和良性区域之间的对比度始终较高.
- 观察到改善的对比度归因于癌症和良性组织之间的增殖率和原沉积的差异.
- 介绍了各种乳腺癌亚型的d-OCT成像,突出了增强的可视化能力.
结论:
- 动态OCT (d-OCT) 显示了改善乳腺保护手术中手术内瘤边缘评估的显著潜力.
- 由d-OCT提供的增强对比度可能有助于外科医生更有效地区分瘤边缘.
- 需要进一步的研究和临床验证,以将d-OCT纳入乳腺癌的标准外科实践.
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