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用流量转移支架治疗的内动脉瘤中的流体动力学:多个几何参数的影响

Fanette Chassagne¹, Michael C Barbour², Michael R Levitt^2,3,4

¹SAINBIOSE INSERM U1059, Mines Saint-Étienne, F-42023 Saint-Étienne, France.

Journal of fluid mechanics

|August 14, 2025

概括

转流支架 (FDS) 对于治疗内动脉瘤至关重要. 这项研究表明,受流量数和动脉瘤几何学影响的血液动力学显著影响了FDS治疗结果.

科学领域:

生物医学工程生物医学工程
流体动力学流体动力学
医疗成像医学成像

背景情况:

内动脉瘤存在生长和破裂的风险.
动脉瘤内的血液动力学对于了解疾病进展和治疗疗效至关重要.
转流支架 (FDS) 是一种关键的治疗方式,但它们的成功取决于复杂的流动动力学.

研究的目的:

调查流量参数 (雷诺兹,迪恩,沃默斯利数) 和动脉瘤几何学对血液动力学的综合影响.
为了评估FDS治疗前后的血液动力学变化.
在理想化内动脉瘤模型中确定影响流动模式的关键因素.

主要方法:

粒子图像速度计 (PIV) 用于分析流动模式.
研究了8种理想化的圆形动脉瘤模型,其母血管曲率,囊面比和子尺寸各不相同.
在模拟FDS治疗之前和之后评估了血液动力学参数.

主要成果:

在大多数模型前处理中观察到单个反旋转,随着雷诺兹数,迪恩数,子尺寸和面积比的增加而加强.
在FDS处理后,出现了四种不同的流动拓:没有分离,部分分离,两个对立的,或单个反旋转的.
院长号和母血管曲率被确定为影响治疗前后血液动力学的主要因素.

结论:

血液动力学在FDS对内动脉瘤的有效性中发挥着关键作用.
动脉瘤的几何和流动特征显著改变了动脉瘤内流动模式.
未来的研究应该纳入患者特定的几何形状和FDS孔隙性,以实现更准确的建模.

关键词:

生物医学流动生物医学流动血液的流动,血液的流动.

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