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认知障碍的负担认知障碍的负担
Tadeja Gracner1,2, Ritika Chaturvedi1,3, PhuongGiang Nguyen2,3
1Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
概括
轻度认知障碍 (MCI) 占认知障碍 (CI) 总负担的41%,不成比例地影响早期CI患者. 这突显了不同人群的重大经济和生活质量影响.
科学领域:
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
- 老年学是一门学科.
背景情况:
- 认知障碍 (CI),包括阿尔茨海默病和相关痴呆症 (ADRD) 和轻度认知障碍 (MCI),影响超过10%的老年人.
- 轻度认知障碍 (MCI) 通常在ADRD之前,并且可以在生命的早期发生,但全面的负担估计是有限的.
- 早期开始的CI (65岁之前) 代表了CI负担的显著而不足量化的方面.
研究的目的:
- 估计认知障碍 (CI) 的终身负担,包括ADRD和MCI.
- 根据疾病进展,发病年龄和社会人口统计因素分析CI负担.
- 量化CI的经济和生活质量影响.
主要方法:
- 微模拟模型被用来估计CI负担在剩余的生命年.
- 该研究分析了51/52岁的美国人,他们患有CI,考虑到疾病进展和发病年龄.
- 负担被计算为与假设的CI预防场景相比,质量调整后寿命年 (QALYs) 和经济结果的差异.
主要成果:
- 人均终身CI负担估计为124,000美元,主要是由失去的QALYs驱动的.
- 总体CI负担达到了6270亿美元,其中ADRD占59%,MCI占41%.
- 早期开始的CI人均负担最高 (376,000美元),MCI的贡献很大. 在受教育程度较低的个人和少数民族种族/族群中观察到不成比例的负担.
结论:
- 轻度认知障碍 (MCI) 占CI总负担的很大一部分 (41%).
- 早期开始的CI承担着特别高的人均负担,其中MCI是主要组成部分.
- 在CI负担方面存在显著的健康和经济差异,不成比例地影响特定的社会人口统计学子组.
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