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在CASP16中模型质量评估的亮点

Alisia Fadini1, Recep Adiyaman2, Shaima N Alhaddad2

  • 1Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

Proteins
|August 14, 2025
PubMed
概括

本研究评估了在CASP16.16期间结构生物信息学中的模型质量评估方法. 测试了用于预测蛋白质结构准确性的领先方法,揭示了它们的优缺点.

关键词:
计算分子生物学计算分子生物学分子模型 分子模型蛋白质构成的结构.蛋白质领域的蛋白质域.

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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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