在多阶段贝叶斯随机临床试验中基于漂移参数的样本大小确定
Yueyang Han1, Haolun Shi1, Jiguo Cao1
1Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada.
Pharmaceutical statistics
|August 14, 2025
概括
贝叶斯随机二期试验的样本大小计算现在更快了. 我们的新方法将组序列和贝叶斯设计联系起来,显著减少精确样本大小确定计算时间.
科学领域:
- 生物统计学 生物统计学
- 临床试验设计 临床试验设计
- 贝叶斯统计学 贝叶斯统计学
背景情况:
- 在贝叶斯随机二期试验中确定样本大小是计算密集的.
- 现有的方法对可行性和效率提出了挑战.
研究的目的:
- 开发一种新的,计算效率高的方法,用于贝叶斯随机二期试验中的样本大小计算.
- 为了减少与样本大小确定相关的计算时间.
主要方法:
- 连接组序列设计与贝叶斯试验设计.
- 利用样本大小和平方漂移参数之间的比例关系.
- 采用回归分析来准确地确定样本大小.
主要成果:
- 显著减少样本大小计算的计算负担.
- 通过理论证明和广泛的数值评估验证了有效的方法.
- 在各种试验场景 (二进制,正常,普通,生存终点) 中证明了效率.
结论:
- 拟议的方法为贝叶斯二期试验中样本大小的确定提供了更快,更有效的算法.
- R包"BayesSize"有助于这些新方法的实际应用.
- 这种方法提高了贝叶斯试验设计在临床研究中的可行性.
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