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慢性轻度炎症与胃肠道手术后不良结果的关联:观察性和门德尔随机化研究
Doruk Orgun1, Christina Ellervik2,3,4,5, Henrik Enghusen Poulsen2,6,7
1Center for Surgical Science, Department of Surgery, Zealand University Hospital Køge, Køge, Denmark.
BJS open
|August 14, 2025
概括
根据高敏感性C反应蛋白 (hs-CRP) 水平显示的基线低度炎症,与胃肠道手术后并发症和死亡风险增加有关. 这一发现强调了评估手术患者慢性炎症的重要性.
科学领域:
- 胃肠病学 胃肠病学
- 炎症研究 炎症研究
- 外科手术的结果
背景情况:
- 手术前的开放性全身炎症与糟糕的结果有关.
- 基线低度炎症对胃肠道手术结果的影响尚不清楚.
研究的目的:
- 为了研究基线高灵敏性C反应蛋白 (hs-CRP) 水平和胃肠道手术患者的术后结果之间的关联.
- 为了确定慢性低度炎症是否预测并发症和死亡率.
主要方法:
- 从哥本哈根总人口研究中分析了一组12803名从2003年至2015年期间接受胃肠道手术的个人.
- 评估了基线hs-CRP水平和遗传变异 (IL6R rs4537545,CRP rs1130864) 的情况.
- 多变量考克斯回归模型被用于评估与30天并发症和90天/5年死亡率的关联.
主要成果:
- 处于最高hs-CRP四分位数 (≥2.73 mg/l) 的个体表现出明显更高的风险:30天并发症为1.19,90天死亡率为1.29,5年死亡率为1.17.
- 使用hs-CRP测量更接近手术的灵敏度分析显示了更大的效果估计.
- 基因预测的hs-CRP水平与不良结果无关.
结论:
- 基线hs-CRP水平升高 (≥2.73 mg/l),表明慢性轻度炎症,与胃肠道手术后30天并发症和死亡风险增加有关.
- 这些发现表明,慢性炎症是手术结果的重要风险因素.
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