阴暗的年龄,阴暗的预后:表观遗传衰老预测胰腺手术风险
Sophie Kollbeck1,2, Carsten Palnæs Hansen1, Mikkel T Bonde1,2
1Department of Digestive Diseases, Transplantation and General Surgery,Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark.
Annals of surgery
|August 14, 2025
概括
使用格林时钟的表观遗传年龄加速 (EAA) 预测胰腺癌患者的结果会更差. 高格林EAA与生存率降低,并发症增加和化疗失败有关.
科学领域:
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 外科手术的结果
背景情况:
- 胰腺管腺癌 (PDAC) 切除提供了唯一的治疗方法,但术后风险和生存预测具有挑战性.
- 现有的风险评估无法充分预测PDAC患者的术后并发症,辅助化疗完成或整体存活期 (OS).
- 表观遗传衰老加速 (EAA) 通过DNA甲基化反映了生物衰老,并可能提供新的预测见解.
研究的目的:
- 评估EAA与OS的关联,使用Horvath,Pheno和Grim时钟.
- 评估EAA与术后并发症的相关性.
- 确定EAA与在可切除PDAC中未能完成辅助化疗的关系.
主要方法:
- 对332名因PDAC而接受胰腺手术的患者进行前性队列研究.
- 排除非PDAC组织学,不可切除的疾病或新辅助化疗的患者.
- 使用Infinium MethylationEPIC v2.0套件进行手术前血液样本的DNA甲基化分析.
主要成果:
- 较高的手术前格林EAA与整体存活率降低相关 (HR 1.12;P=0.024).
- 严重的术后并发症增加与更高的格林EAA相关 (OR 1.77;P=0.008).
- 未能完成辅助化疗与更高的格林EAA (OR 1.47;P<0.0001) 有关.
结论:
- 格林EAA显示了作为可切除PDAC的手术前风险分层工具的潜力.
- 这种表观遗传标记可能有助于为PDAC患者个性化治疗策略.
- 在临床实施Grim EAA之前,需要进行进一步的验证研究.
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