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用于口腔粘膜生物制造的组织工程:系统审查和元分析.

Miguel A Martin-Piedra1,2, Manuel Albendin-Moreno1, Adriana Olivares-Abril1

  • 1Tissue Engineering Group, Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain.

Tissue engineering. Part B, Reviews
|August 14, 2025
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概括

组织工程口腔粘膜显示了口腔损伤重建的临床潜力. 使用角质细胞和纤维细胞的生物制造进步为人工口腔粘膜的发展带来了有希望的结果.

关键词:
通过先进的治疗方法.这是一个元分析.在口腔的粘膜.系统性审查 系统性审查组织工程是组织工程.

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科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 组织工程是组织工程.

背景情况:

  • 口腔粘膜重建对于治疗口腔病变至关重要.
  • 组织工程为传统方法提供了一个有希望的替代方案.
  • 人工口腔粘膜的开发正在迅速推进.

研究的目的:

  • 系统地审查和元分析人工口腔粘膜生物制造方面的进展.
  • 评估组织工程口腔粘膜的组件,方法和结果.
  • 评估当前生物制造技术的临床潜力.

主要方法:

  • 57项研究的系统审查和元分析.
  • 专注于临床前体外研究.
  • 对细胞来源,生物材料和生物制造技术的分析.

主要成果:

  • 主要的细胞来源:口腔角质细胞和纤维细胞;生物材料:原蛋白.
  • 浸泡和空气技术是主要的生物制造方法.
  • 平均上皮质厚度:73.18微米;成熟度得分:5.13/6. 在体内研究显示了更好的分层.

结论:

  • 组织工程口腔粘膜显示出临床应用的巨大潜力.
  • 进一步的研究可能会优化上皮质厚度和分层.
  • 生物制造策略是成功的口腔粘膜再生的关键.