所有生物都可以麻醉,但没有意义吗?
Lucia Sylvain-Bonfanti1,2, Delphine Arbelet-Bonnin1, Christophe Lalanne1
1Laboratoire Interdisciplinaire des Énergies de Demain (LIED UMR 8236), Université Paris-Cité, Paris, France.
概括
麻醉剂向电压依赖的Na+/Ca2+通道等必需蛋白质,这表明麻醉易感性源于固有的细胞弱点,而不仅仅是自然选择.
科学领域:
- 生物化学 生物化学
- 进化生物学 进化生物学
- 神经科学是一个神经科学.
背景情况:
- 从历史上看,麻醉研究主要集中在动物的神经系统上,忽视了所有生命形式的麻醉潜力.
- 麻醉剂与保存的蛋白质相互作用,包括电压依赖的Na+/Ca2+通道 (4D-NaV/CaV) 和谷氨酸受体通道 (iGluR/GLR),存在于各种物种中.
- 这些必不可少的蛋白质很早就进化了,比真核生物更早,并表明它们的保护有着强大的选择性压力.
研究的目的:
- 为广泛的麻醉易感性提出一个替代假设.
- 挑战普遍的观点,即麻醉敏感性仅仅是自然选择的结果.
主要方法:
- 针对不同物种的麻醉剂向的蛋白质同类体的比较分析.
- 对电压依赖的Na+/Ca2+通道和谷氨酸受体通道的进化起源的审查.
- 基于保存的蛋白质标和细胞功能的假设制定.
主要成果:
- 识别了保护蛋白标 (4D-NaV/CaV,iGluR/GLR) 对于广泛的物种中细胞功能至关重要.
- 证明这些目标早于真核生物,突出了它们在生命中的基本作用.
- 突出了强大的选择性压力,维持了这些重要通道.
结论:
- 大多数生物体对麻醉的敏感性可能源于细胞内在的脆弱性,而不是仅仅来自自然选择.
- 这种内在的弱点与细胞生命所必需的向离子通道的基本性质和保护有关.
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