在艾滋病毒感染的老年人中了解感知药丸负担:探索临床和人口决定因素
Chukwuemeka N Okafor1, Deanna Ware2, Liddy Kasraian2
1Department of Medicine, Division of Infectious Diseases, University of Texas Health & School of Public Health, San Antonio, TX, USA. okaforcn@uthscsa.edu.
AIDS and behavior
|August 14, 2025
概括
艾滋病毒感染的老年人可能会感到被药物治疗计划所压倒. 抑郁症和服用更多的药丸显著增加了这种感知到的药丸负担,突出了综合护理的需要.
科学领域:
- 老年学是指老年学的学科.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 艾滋病毒感染的老年人 (PWH) 经常管理多种并发症,可能会增加他们感知的药物负担.
- 被认为的药丸负担是与药物治疗方案相关的主观困难,影响治疗坚持和生活质量.
研究的目的:
- 调查与中年和老年艾滋病毒感染者 (MWH) 感知药物负担相关的人口统计,心理社会和临床因素.
主要方法:
- 从多中心艾滋病队列研究中分析了586名年龄≥40岁的MWH的数据.
- 通过药片的频率和数量来评估感知到的药片负担,分为"负担"和"没有负担".
- 后勤回归用于识别相关因素,包括抑郁症状 (CES-D分数≥16).
主要成果:
- 显著的抑郁症状与感知药片频率 (aOR: 2.79) 和量负担 (aOR: 2.08) 的概率增加有关.
- 更多的艾滋病毒和非艾滋病毒药物与感知到的更大的药物负担有积极的关联.
- 参与者的平均年龄为59岁,其中56.8%的人认为自己是非西班牙裔白人.
结论:
- 抑郁症和多种药物是导致老年MWH患者感知到药物负担的关键因素.
- 对于管理艾滋病毒和并发症的老年MWH,建议定期对感知药物负担和抑郁症进行查.
- 需要进行纵向研究,以了解感知药片负担的长期轨迹.
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