改变了情绪感知和调节网络的有效连接,在情绪面部感知任务中,在成年人中,有酒精使用障碍
Christopher J Hammond1, Liangsuo Ma2,3, James M Bjork2,3,4
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5500 Lombard Street, Baltimore, MD, 21224, USA.
Brain structure & function
|August 14, 2025
概括
患有酒精使用障碍 (AUD) 的人在情绪处理过程中显示出大脑连接的改变. 这些有效连接 (EC) 的中断与酒精暴露和抑郁症有关,影响情绪调节.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成研究 研究成研究
背景情况:
- 情绪失调和情绪障碍与酒精使用障碍 (AUD) 风险有关.
- 这些关联背后的特定神经电路仍然不太清楚.
研究的目的:
- 与对照人群相比,研究AUD患者在情感面部处理过程中有效连接 (EC) 的变化.
- 检查改变的EC,累积的酒精暴露和情绪症状 (抑郁,焦虑) 之间的关系.
主要方法:
- 分析了来自人类结合体项目的功能性MRI数据.
- 动态因果建模 (DCM) 用于评估关键大脑区域 (VMPFC,VLPFC,AMY,FG,HTN) 的EC群体差异.
- 线性回归与EC与酒精暴露,抑郁和焦虑得分相关.
主要成果:
- 与对照组相比,AUD参与者表现出明显不同的EC模式,包括减少VMPFC → 双边VLPFC连接和增加VMPFC → VMPFC自我连接.
- 改变的皮层到皮层和皮层到子皮层EC与AUD组的累积酒精暴露有关.
- 从右侧VLPFC到左侧FG减少的EC与抑郁症严重程度有负相关性.
结论:
- 患有AUD的个体在情绪面部处理过程中,在情绪调节大脑电路内表现出被破坏的有效连接.
- 这些神经变化可能是重度饮酒,情绪控制受损和抑郁症状之间的关系的基础.
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