用局部巨细胞调节 (ON101) 改善糖尿病足部伤口愈合:一个案例系列
Kwan Lok Benjamin Ng1, Yun-Nan Lin1,2, Wei-Yu Chen1
1Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Journal of wound care
|August 14, 2025
概括
一种新的局部,ON101,有效治疗糖尿病足 (DFU),促进肢体救援和患者满意度. 这项研究强调了其作为慢性DFU有前途的治疗潜力.
科学领域:
- 皮肤病学 皮肤病学
- 伤口愈合 治愈 伤口愈合
- 足部医学是一门专业.
背景情况:
- 糖尿病足 (DFU) 是糖尿病的一个严重并发症,经常导致严重的发病率和肢体损失.
- 目前慢性DFU的治疗方法存在局限性,需要新的治疗方法.
研究的目的:
- 评估ON101的现实有效性和安全性,它是一种局部巨细胞调节奶油,用于治疗难以愈合的糖尿病足.
主要方法:
- 一个涉及10名患有脚和足部表面慢性DFU的患者的病例系列.
- 在最初的伤口治疗 (脱bridement,血管整形) 后,ON101 (含有*Plectranthus amboinicus*和*Centella asiatica*提取物) 被局部应用每天最多两次.
- 创伤愈合,并发症和患者的结果都被精心记录下来.
主要成果:
- 大多数10名患者在ON101治疗后实现了无并发症的伤口愈合,治疗时间从14天到264天不等.
- 一名患有骨髓炎的患者没有完全康复,但所有参与者都对结果表示满意.
- 在六个月的随访期间没有报告任何并发症,这表明了有利的安全性.
结论:
- 在这种糖尿病足的病例系列中,ON101表现出良好的治愈效果.
- 局部应用ON101似乎是一个有希望的策略,以实现肢体救援结果在DFU管理.
关键词:
在 ON101 上,我们可以看到慢性 慢性 慢性 慢性糖尿病患者的糖尿病脚药物治疗是药物治疗.难以治愈的难以治愈的巨细胞是一个巨细胞.的发作 的发作 的发作伤口的伤口是伤口.伤口护理 伤口护理伤口上使用了伤口带.伤口愈合 伤口愈合更多相关视频
10:49Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
4.6K
09:06Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
Published on: March 25, 2020
8.8K
相关概念视频
01:28Phases of Wound Repair
6.4K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.4K
01:19Clinical Applications of Epidermal Stem Cells
2.8K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.8K