颗粒物成分和移植后结果在移植接受者中
Yijing Feng1,2, Yiting Li2, Sunjae Bae2,3
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
JAMA network open
|August 14, 2025
概括
微粒颗粒物 (PM2.5) 构成的空气污染,如硫酸盐,,有机碳和,与不良的移植结果有关. 硫酸盐会影响长期结果,而,有机碳和会影响短期结果.
科学领域:
- 环境健康 环境健康
- 移植科学 移植科学
- 毒理学 毒理学 毒理学
背景情况:
- 细颗粒物 (PM2.5) 与移植 (KT) 的负面结果有关.
- PM2.5是一种复杂的混合物,具体成分在后KT结果中的作用尚不清楚.
研究的目的:
- 调查PM2.5特定成分与KT后不良结果之间的关联.
- 确定哪些PM2.5成分最显著地影响移植成功.
主要方法:
- 一项对2000年至2016年期间在连续美国的192,587名KT接受者的队列研究.
- 通过使用加权量子式总量回归,研究了15个PM2.5成分 (例如,OC,Ni,Pb,SO42-) 和结果 (急性排斥,DGF,DCGF,死亡率) 之间的关联.
主要成果:
- 增加的PM2.5混合物与更高的DGF概率 (6.8%) 和急性排斥 (3.6%) 相关.
- 有机碳 (OC) 和 (Ni) 导致了DGF风险; (Pb) 导致了急性排斥风险.
- PM2.5混合物增加了DCGF (4.7%) 和死亡率 (3.9%) 的危险性,硫酸盐 (SO42-) 是主要的贡献者.
结论:
- PM2.5成分与KT后不良结果的风险增加有关.
- 硫酸盐 (SO42-) 与长期结果有关,而 (Pb),有机碳 (OC) 和 (Ni) 与短期结果有关.
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