全球儿童癌症存活率:系统性审查
Melissa Martos1, Nicholas George1, Farina E Arreguín-González2
1Department of Pediatrics, Division of Hematology/Oncology, University of Washington, Seattle.
JAMA oncology
|August 14, 2025
概括
儿童癌症幸存率研究集中在高收入国家,身体影响是最受研究的领域. 全球数据并不反映幸存者人口,需要增加对不同地区和研究领域的研究支持.
科学领域:
- 全球健康 全球健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 在全球范围内,儿童癌症的存活率正在上升,导致越来越多的幸存者面临更高的长期健康问题的风险.
- 现有的儿童癌症幸存率研究缺乏全球总结,特别是高收入国家 (HIC) 和低收入和中等收入国家 (LMIC) 的比较.
研究的目的:
- 系统地审查和描述儿童癌症幸存者研究的全球分布.
- 根据原产国,研究重点和幸存者领域分析研究,比较HIC和LMIC.
主要方法:
- 1980年至2021年间发表的研究进行了系统审查,使用多个数据库 (全球指数Medicus,CAB Direct,Embase,PubMed).
- 如果这些研究专注于儿童癌症幸存者 (在20岁之前被诊断出),并评估了幸存者结果或多病症,则将这些研究纳入.
- 数据按国家收入群,世卫组织地区和生存领域 (精神,身体,心理社会健康,复发,新癌症,健康促进) 分类.
主要成果:
- 包括来自43个国家的1558项研究,HICs (95.2%) 和世卫组织美洲/欧洲地区 (92.5%) 的比例不成比例.
- 来自LMIC的研究比例随着时间的推移而增加.
- 物理效应是研究的主要生存领域,特别是在LMIC与HIC相比. 在HICs的研究具有更大的样本大小和更广泛的数据源.
结论:
- 目前的儿童癌症幸存者研究机构并不充分代表全球幸存者人口.
- 全球所有儿童癌症幸存者获得公平的长期成果,需要加强对代表性不足地区和多样化研究领域的研究的支持.
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