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Updated: Sep 11, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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53BP1调节了p53-E2F7依赖的转录基因抑制,并参与了Fanconi贫血路径

Yundong Fu1, Wei Wu1, Maosha Zhang1

  • 1Department of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, P.R. China; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, P.R. China.

Cell reports
|August 14, 2025
PubMed
概括

结合p53的蛋白1 (53BP1) 在未受到压力的细胞中负面调节E2F7的表达. 这种依赖H4K20me2的调节影响了Fanconi贫血路径和DNA交叉链接的敏感性.

关键词:
53BP1BP1是什么意思科普:分子生物学 分子生物学E2F7 E2F7 E2F7 E2F7 E2F7 E2F7 E2F7 E2F7芬科尼贫血的途径在 p53 里,p53 是一个 p53 的类型.

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