在1岁以下的婴儿中,nirsevimab和急性支气管炎的入院情况
David Andina Martínez1,2, Gemma Claret Teruel3,4,5, Manuel Gijón Mediavilla6
1Pediatric Emergency Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Pediatric pulmonology
|August 14, 2025
概括
大多数患有支气管炎的住院婴儿都是6个月以上的健康儿童,不符合Nirsevimab的资格. 这突显了呼吸道同胞性病毒 (RSV) 预防覆盖的差距.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 西班牙开始使用nirsevimab进行通用呼吸道同胞病毒 (RSV) 预防.
- 这项干预措施实现了支气管炎入院病例的显著减少 (60%-80%).
研究的目的:
- 为了描述住院患有支气管炎的婴儿,在nirsevimab后实施.
- 在现实环境中评估nirsevimab的有效性.
主要方法:
- 在15个西班牙儿科急诊室进行了回顾性研究.
- 纳入标准:在2023-2024年RSV季节,12个月以下的婴儿因急性支气管炎住院治疗.
主要成果:
- 分析了947名患有支气管炎的婴儿.
- 20.9%的人没有资格接受nirsevimab (年龄大于6个月,没有并发症).
- 在符合条件的婴儿中,50.3%接受了nirsevimab;49.7%没有. 没有接种疫苗的婴儿的RSV阳性程度更高 (86.5%vs42.1%). 免疫和未免疫的RSV支气管炎婴儿在PICU入院或停留时间没有显著差异.
结论:
- 预防后的支气管炎入院主要涉及健康的婴儿>6个月,有资格但未免疫的婴儿,以及免疫的非RSV感染的婴儿.
- 需要进一步的研究来了解与RSV支气管炎住院的免疫婴儿的结果.
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