布尔控制网络的强有力的输出跟踪 受到随机函数扰乱的影响
IEEE transactions on computational biology and bioinformatics
|August 14, 2025
概括
随机函数扰动 (SFP) 可以影响布尔控制网络 (BCN). 本研究提供了验证SFPs影响的方法,并推导了在BCN中强大的输出跟踪条件,即使有扰动.
科学领域:
- 系统生物学 系统生物学
- 控制理论 控制理论
- 计算生物学 计算生物学
背景情况:
- 布尔控制网络 (BCN) 用于模拟复杂的生物系统.
- 随机函数扰动 (SFPs) 可以在NCB模型中引入不确定性.
- 了解SFP的影响对于NCB可靠分析至关重要.
研究的目的:
- 调查SFPs对BCNs输出跟踪的影响.
- 制定评估SFP对NCB国家转型影响的标准.
- 在存在SFPs时建立可靠输出跟踪的条件.
主要方法:
- 为BCN与SFP建立过渡概率矩阵.
- 开发一种标准来检测SFP对状态过渡的影响.
- 构建一个基于原始BCN和SFP的扰乱参数集.
- 推导出可靠输出跟踪的必要和足够条件.
主要成果:
- 提出了一个标准,以确定SFP是否影响NCB国家过渡.
- 根据SFPs来导出有限时间和非对称输出跟踪的必要和充分条件.
- 理论结果使用布尔模型验证了E. coli中lac操作的理论结果.
结论:
- SFPs可以显著影响 BCN 的行为和输出跟踪.
- 开发的方法为分析和确保扰乱BCN的稳健控制提供了一个框架.
- 这项研究提供了关于生物调节网络对随机噪声的弹性方面的见解.
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