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Updated: Sep 11, 2025

Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution
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Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution

Published on: February 26, 2019

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CrisprDA:一种数据增强方法,提高sgRNA在目标活动预测中的效率.

Hao Chen, Zhenran Jiang

    IEEE transactions on computational biology and bioinformatics
    |August 14, 2025
    PubMed
    概括

    这项研究介绍了Automix和CNLC用于CRISPR/Cas9基因组编辑,通过解决数据稀缺问题来增强单导向RNA (sgRNA) 活动预测. 使用深度学习的新型CrisprDA模型显著提高了预测准确度.

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    A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells

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    Homologous Recombination

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