Xsurvey:用于查询所有参考蛋白质组的同重复组的网络工具
IEEE transactions on computational biology and bioinformatics
|August 14, 2025
概括
同一重复,低复杂性蛋白质区域,现在可以使用Xsurvey.在物种之间进行比较. 这个网络工具分析了23,150个蛋白质组,使得氨基酸重复使用的视觉比较更容易解释.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 同重复性蛋白质是蛋白质序列中复杂性较低的区域,其特征是重复的氨基酸残留物.
- 目前,由于缺乏自动化工具,对不同物种的同类重复组进行比较是具有挑战性的.
研究的目的:
- 介绍Xsurvey,这是一个新的网络工具,旨在自动比较跨多个物种的同类重复群.
- 为了促进大规模蛋白质组数据集中的同重复模式的分析和解释.
主要方法:
- Xsurvey查询了23,150个完全测序的蛋白质组的数据库.
- 该工具计算和可视化polyX使用值,表示特定氨基酸重复的频率.
主要成果:
- 这项研究将Xsurvey作为一种功能性网络工具来进行同源重复分析.
- 对polyX使用值的视觉比较简化了对跨物种同重复分布的解释.
结论:
- Xsurvey提供了第一个自动化方法来比较跨不同物种的同类重复群.
- 该工具通过对低复杂度区域进行大规模比较分析来增强蛋白质序列演变和功能的研究.
更多相关视频
17:12Profiling of Methyltransferases and Other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry CCMS
Published on: December 20, 2010
15.7K
09:10A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
9.3K
相关概念视频
Proteomics
7.9K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.9K
Ribosome Profiling
3.6K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.6K
Conservation of Protein Domains Over Different Proteins
11.4K
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
11.4K
Protein Families
15.7K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...
15.7K
Protein Networks
4.1K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.1K
