相关实验视频

Updated: Sep 11, 2025

A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization
08:20

A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization

Published on: September 2, 2021

4.2K

一个改进的条件瓦瑟斯坦GAN与梯度惩罚基因表达简介数据增强基于数据分割和深度特征约束的基因表达简介数据增强.

Fei Han, Yutao Liang, Qinghua Ling

    IEEE transactions on computational biology and bioinformatics
    |August 14, 2025
    PubMed
    概括

    这项研究引入了带有梯度惩罚的改进条件瓦斯斯坦生成对抗网络 (CWGAN-GP),以增强基因表达分析数据. 该方法提高了医疗诊断的数据质量和培训稳定性.

    更多相关视频

    Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers03:37

    Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

    Published on: March 1, 2024

    894
    Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans09:23

    Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

    Published on: August 16, 2017

    8.2K

    相关概念视频

    Improving Translational Accuracy02:07

    Improving Translational Accuracy

    Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
    11.9K
    Genome-wide Association Studies-GWAS01:11

    Genome-wide Association Studies-GWAS

    Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
    GWAS does not require the identification of the target gene involved in...
    14.2K
    One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

    One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

    This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
    On...
    712
    Combinatorial Gene Control02:33

    Combinatorial Gene Control

    Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
    The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
    8.4K
    Mutation, Gene Flow, and Genetic Drift01:09

    Mutation, Gene Flow, and Genetic Drift

    In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
    59.5K
    Genetic Drift03:33

    Genetic Drift

    Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
    40.7K