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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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相关实验视频

Updated: Sep 11, 2025

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
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区分甲状腺癌中的TSH切断和复发风险:系统性审查和元分析.

Yoon Young Cho1, Soo Hyun Ahn2, Mijin Kim3

  • 1Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea.

The Journal of clinical endocrinology and metabolism
|August 14, 2025
PubMed
概括

抑制甲状腺刺激激素 (TSH) 总体上没有显著影响差异化甲状腺癌复发. 然而,TSH抑制可能会降低远程转移的高风险患者的复发风险.

关键词:
在 TSH 中,您可以使用复发性 复发性 复发性压抑的压抑是一种压抑.甲状腺癌是一种癌症.

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科学领域:

  • 内分泌学 在内分泌学.
  • 在瘤学瘤学.
  • 临床研究 临床研究

背景情况:

  • 差异化甲状腺癌 (DTC) 管理通常涉及TSH抑制.
  • 最佳的TSH水平以最大限度地降低复发风险仍在争论中.
  • 美国甲状腺协会 (ATA) 分层了DTC复发风险.

研究的目的:

  • 评估TSH水平与DTC复发风险之间的关联.
  • 根据可变的TSH切断值 (0.1,0.5,2.0 mIU/L) 来分析复发率.
  • 根据ATA风险类别分层调查TSH的作用.

主要方法:

  • 在Ovid-Medline,EMBASE和Cochrane数据库中进行系统搜索 (截至2024年3月).
  • 包括随机对照试验和观察性研究.
  • 基于TSH切线和ATA风险分层的元分析和子组分析.

主要成果:

  • 对5320名患者的分析,整体复发率为18%.
  • 在TSH切断值 (0.1,0.5,2.0 mIU/L) 中,聚合复发风险没有显著差异.
  • 在敏感性分析中,在TSH ≥0.1 mIU/L和TSH ≥2.0 mIU/L时观察到复发风险增加;在TSH ≥0.1 mIU/L时,患有远程转移的患者 (HR 3.3) 的风险更高.

结论:

  • TSH抑制程度没有影响整体DTC复发.
  • 对于具有远程转移的高风险DTC患者来说,TSH抑制可能是有益的.
  • 进一步的研究可能会澄清TSH在特定患者亚组中的作用.