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Updated: Sep 11, 2025

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在HPLC指纹和Inonotus hispidusus的抗瘤活动之间的频谱效应关系

Changsong Xu¹, Hongyu Niu¹, Xinghao Liu¹

¹School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

|August 14, 2025

概括

伊诺诺斯皮的抗瘤特性与多种协同作用的化合物有关,特别是hispidin. 主要活性成分集中在乙酸乙烯分量中,验证了其药用潜力.

科学领域:

菌类学菌类学是指菌类学.
药理学药理学是指药理学的学科.
自然产品化学自然产品化学

背景情况:

(I. hispidus) 是一种传统上用于药用目的的真菌.
它表现出已知的抗瘤,抗氧化剂和低血糖活性.
负责其抗瘤作用的特定化学成分需要进一步阐明.

研究的目的:

为了确定HPLC指纹的I. hispidus批量.
评估I.hispidus对4T1和HeLa细胞的抗瘤活性.
通过化学测量方法,将化学特征与抗瘤活性相关联.

主要方法:

高性能液态染色学 (HPLC) 指纹.指纹.
用于细胞活力评估的MTT试验.
灰色关系分析和部分最小平方回归用于相关性分析.

主要成果:

对11批I. hispidus. 的HPLC指纹进行了确定.
观察到对4T1和HeLa细胞有显著的抑制作用.
峰值3,5 (hispidin),6和7被确定为抗瘤活性的主要贡献者.
发现这些活性成分在乙酸乙烯分量中得到了丰富.

结论:

伊希斯皮杜斯的抗瘤活性来自于多种化学成分的协同作用.
希斯皮丁和其他已识别的化合物对其抗癌性质至关重要.
这项研究为I. hispidus的传统使用提供了科学基础,并澄清了其频谱效应关系.

关键词:

它具有抗瘤效果.通过HPLC进行指纹检查.这种植物是Inonotus hispidus.频谱效应关系的频谱效应关系

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