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从微观结构到机械:动脉组织的多组分微观计算模型

M Pétré¹, H Wolfs², L Maes²

¹Institute of Mechanics, Materials and Civil Engineering (iMMC), UCLouvain, Belgium; Institut de recherche expérimentale et clinique (IREC), UCLouvain, Belgium; Dpt. Mechanical Engineering, KU Leuven, Belgium.

Computers in biology and medicine

|August 14, 2025

概括

这项研究模拟了动脉组织微观结构,以了解弹性素和原蛋白如何影响机械行为,这对心血管疾病研究至关重要. 该模型揭示了弹性斑块控制了初始反应,而原则决定了非线性行为.

科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
组织力学组织力学

背景情况:

动脉组织经历复杂的生长和重塑,由响应机械和生化线索的细胞调节.
了解动脉微观结构 - 机械行为对于表征心血管疾病如高血压和动脉样硬化至关重要.

研究的目的:

开发猪大动脉中层的基于微结构的代表体积元素 (RVE) 模型.
研究弹性纤维,弹性纤维,原纤维和光滑肌肉细胞的机械贡献.

主要方法:

使用对比度增强的X射线微焦计算机断层扫描 (CECT),多光子显微镜,组织学和扫描电子显微镜 (SEM) 构建了RVE几何.
从文献中分配组件的机械性能,并根据实验拉伸试验数据验证了模型.
进行了尺寸收,网格收和参数灵敏度分析.

主要成果:

一个RVE与11个中间叶片单元被发现是必要的代表性宏观机械反应.
材料的刚度和弹性质和原体的体积百分比显著影响应激反应.
弹性叶片主导最初的线性应力-应变区域,而原纤维则控制非线性行为.

结论:

开发的RVE模型准确地代表了猪大动脉中介层的机制.
弹性蛋白和原相互作用是动脉组织机械行为的关键决定因素.
这项研究为细胞外矩阵相互作用和疾病中的组织重塑提供了宝贵的见解.

关键词:

动脉组织的动脉组织.微结构成像技术微结构成像多尺度建模多尺度建模代表性的体积元素体积元素.

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