当地和利基适应的睡眠调节机制涵盖了全生物体的条件
Erika L English1, James M Krueger2
1School of Molecular Biosciences, Washington State University, Spokane, WA, USA.
Sleep medicine reviews
|August 14, 2025
概括
生物体的睡眠是由唤醒电路和局部细胞活动之间的相互作用引起的. 微生物信号和古老的分子,如介质素-1,影响睡眠,这表明这个重要过程的细胞基础.
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
- 微生物学 微生物学
背景情况:
- 睡眠调节传统上归因于复杂的神经电路.
- 细胞活动和微生物相互作用在睡眠中的作用仍然不太清楚.
研究的目的:
- 建议对生物体睡眠进行双重监管模型.
- 探索局部细胞活动和微生物因素在睡眠启动和调节中的作用.
- 审查不同生物组织层次的保存睡眠机制的证据.
主要方法:
- 关于睡眠调节,细胞活动和微生物影响的现有文献的审查.
- 分析睡眠调节物质 (如细胞因子,腺) 的作用及其来源.
- 检查对微生物模式识别受体及其对睡眠状况的影响的研究.
主要成果:
- 睡眠是通过经典的睡眠/觉醒电路和局部细胞活动驱动系统的相互作用来调节的.
- 响应微生物信号的局部睡眠机制可以独立于主要调节电路启动类似睡眠的状态.
- 睡眠调节物质是与细胞活动相关的古老分子,早于复杂的脊椎动物睡眠.
结论:
- 睡眠是细胞网络的新兴特性,从细胞层面开始,并通过调节电路进行修改.
- 古代的全生物条件和保存的细胞机制是跨物种和组织水平的睡眠调节的基础.
- 睡眠调节涉及跨物种网络,受到微生物相互作用和古代信号分子的影响.
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