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Updated: Sep 11, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Published on: May 9, 2025

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计算结构优化增强IL13Rα2 - B7-H3联CAR T细胞,以克服抗原异质介导的瘤逃生

Michaela M Meehl1, Kalyan Immadisetty2, Vikas D Trivedi3

  • 1Department of Bone Marrow Transplantation and Cellular Therapy (BMTCT), St. Jude Children's Research Hospital, Memphis, TN 38105, USA; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Molecular therapy : the journal of the American Society of Gene Therapy
|August 14, 2025
PubMed
概括

使用计算方法设计了一种双向的仿真抗原受体 (CAR) T细胞疗法,提高了它对抗瘤的能力. 这种优化的双重CAR T细胞疗法克服了瘤逃生机制,以更好地治疗癌症.

关键词:
在CAR T细胞中,IL13Rα2 B7-H3 B7-H3 IL13Rα2 B7-H3 IL13Rα2 B7-H3 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 IL13Rα2 B7-H3 B7-H3抗体工程是针对抗体的工程.抗原逃逸的方法是什么?细胞表面表达的优化,细胞表达的优化.计算结构预测 计算结构预测表达方式 健身分数 表达方式 健身分数链接器工程 链接器工程蛋白质工程工程 蛋白质工程坦德姆双特异的CAR是双特异的CAR.

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