老年住院患有认知障碍患者的不良事件
Bo Schouten1, Fleur C W Visser2, Marlise E A van Eersel2
1Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Journal of the American Medical Directors Association
|August 14, 2025
概括
住院老年人的认知障碍并没有显著增加不良事件 (AE) 发生率. 然而,副作用的性质和原因有所不同,这凸显了针对患者的量身定制安全策略的必要性.
科学领域:
- 老年医学 老年医学
- 患者安全 患者安全
- 医疗保健的质量 医疗保健的质量
背景情况:
- 认知障碍在住院的老年人中越来越普遍.
- 认知障碍可能会增加对不良事件 (AE) 的敏感性.
- 了解AE在这个人群中的患病率和特征对于改善护理至关重要.
研究的目的:
- 确定AES,潜在可预防的AES和住院的老年患者的患病率,包括认知障碍和没有认知障碍的老年患者.
- 分析这些患者群体中AE的性质,原因和预防策略.
主要方法:
- 从一项全国性对住院老年已故患者的研究中对1959年的记录进行了回顾性分析.
- 患者根据国际疾病分类,认知障碍第十次修订代码 (妄想症,痴呆症等) 进行了分类. ) 的情况.
- 记录在两个阶段进行了审查,以评估AE,其可预防性,性质,原因和推的预防策略.
主要成果:
- 21.8%的患者有认知障碍;超过90%的患者有查尔森并发症指数≥5.5.
- AE患病率为13.1% (没有障碍) 与17.0% (认知障碍),没有统计学意义 (P=.071).
- 认知障碍患者,特别是妄想症患者,经历的副作用更常与临床管理 (护理) 和组织原因有关.
结论:
- 虽然AE的总体患病率没有显著差异,但AE的类型和原因在认知障碍患者和正常患者之间有所不同.
- 与组织和护理相关的因素是认知障碍个体中AEs的更常见原因.
- 需要进一步的研究来探索脆弱性,多病症,认知障碍和患者安全的相互作用.
相关概念视频
Cognitive Development During Adulthood
275
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
275
Dementia
165
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
165
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
206
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
206
Alzheimer's Disease: Overview
668
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
668
Alzheimer's Disease: Treatment
261
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
261
Negative and Cognitive Symptoms of Schizophrenia
123
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
123


