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Updated: Sep 11, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

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删除与p53相关的蛋白激酶 (PRPK) 通过抑制PD-L1表达和增强CD8 T细胞透来抑制太阳UV诱导的光癌发生

Qiushi Wang1, Eunmiri Roh2, Asad Khan1

  • 1The Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912.

The Journal of investigative dermatology
|August 14, 2025
PubMed
概括

在皮肤细胞中删除与p53相关的蛋白激酶 (PRPK) 抑制非黑色素瘤皮肤癌的生长. 这种方法抑制了瘤的进展,并增强了免疫细胞的活动,为皮肤癌提供了潜在的新疗法.

关键词:
CD8 T 细胞透.在PD-L1中.这就是PRPKK.在SUV引发的皮肤癌.

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