相关实验视频

Updated: Jul 24, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

9.7K

选择性条纹病理变化在一个新的人类HTT外子1敲入鼠标模型的亨廷顿病的选择性条纹病理变化

Tengteng Wu1, Yu Zhang2, Yongchao Li2

  • 1Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.

Experimental neurology
|August 14, 2025
PubMed
概括

一个新的小鼠模型,HEKI-150Q,通过复制关键的遗传和病理特征,准确地模仿亨廷顿病 (HD). 这种模型对研究HD机制和测试针对亨廷丁基因的新疗法充满希望.

关键词:
克里斯普尔-Cas9是什么意思亨廷顿病就是亨廷顿病.这是一次敲门入场.鼠标模型模型

更多相关视频

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy11:22

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Published on: June 27, 2018

8.1K
Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System10:52

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

2.6K

相关概念视频

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...