在青少年大脑认知发展 (ABCD) 研究中,疼痛经历和青春期灰质体积之间的关联
Carmen I Bango1, Scott A Jones2, Sara Shao2
1Department of Psychiatry, Oregon Health & Science University, Portland, OR, United States; Department of Pediatrics, Institute on Development and Disability, Oregon Health & Science University, Portland, OR, United States.
The journal of pain
|August 14, 2025
概括
青春期的疼痛是一个日益关注的问题. 青少年的疼痛得分较高与感觉运动和头顶大脑区域的灰质体积减少有关,特别是右下头顶环.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 年轻人的疼痛是越来越多的公共卫生问题.
- 对成年人的疼痛和大脑形态的研究是广泛的,但对青少年的了解较少.
- 了解青少年疼痛的神经生物学相关性对于早期干预至关重要.
研究的目的:
- 调查7712名青少年 (平均年龄11.96) 的疼痛和灰质体积之间的关联.
- 为了比较过去一个月疼痛和没有疼痛的青少年之间的大脑形态.
- 为了检查疼痛严重程度和特定的大脑区域之间的关系.
主要方法:
- 结构性脑磁共振成像 (MRI) 用于评估82个大脑区域的灰质体积.
- 参与者被分为有 (n=2668) 和没有 (n=5044) 上个月疼痛的组.
- 隐性疼痛因子 (平均疼痛,最严重的疼痛,疼痛限制) 用于分析与灰质体积的关联,并没有对总内体积 (ICV) 的调整.
主要成果:
- 在有或没有月经疼痛的青少年之间,没有发现有意义的整体灰质差异.
- 在六个皮质区域 (前中心,后中心,下,上,侧回旋) 中,更高的潜在疼痛得分与较低的灰质体积相关.
- 在对ICV进行调整后,只有右下侧状回环与更高的疼痛得分有显著的关联,这表明区域特异性.
结论:
- 在青少年中,增加疼痛经历与感觉运动和部区域灰质体积的减少有关.
- 右下垂体环可能是一个关键区域,将青少年的疼痛和大脑结构联系起来.
- 需要进一步的研究来了解这些发现的时间动态和临床影响.
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