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科尔奇辛诱导斑马鱼的发育缺陷和毒性,通过上调氧化应激

Fang Chen¹, Haiyan Wei², Dalong Liao¹

¹The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, China.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

|August 14, 2025

概括

科尔奇辛因增加氧化应激而导致斑马鱼的损伤和发育问题. 阿斯塔克桑 (ASTA) 治疗显示出扭转这些有害影响的潜力.

科学领域:

毒理学毒理学毒理学
腎臟病學 (nephrology) 是一種醫學.
发育生物学发展生物学

背景情况:

科尔奇辛是一种用于痛风性关节炎的类化合物,被怀疑会引起脏毒性.
结衣素诱导的毒性背后的确切机制仍然在很大程度上是未知的.

研究的目的:

为了验证科尔奇辛在斑马鱼中的毒性.
为了阐明素诱导的损伤的机制.

主要方法:

斑马鱼幼虫和成年人暴露在不同度的菌素中.
评估的发育参数,结构 (组织病理学),氧化应激标记,基因表达和损伤生物标记.
评估了阿斯塔山丁 (ASTA) 的保护作用.

主要成果:

科尔奇辛暴露导致死亡率增加,发育迟缓,胀和严重的脏结构损伤,包括细胞胀和管道破坏.
观察到高活性氧物种 (ROS) 和氧化应激激酶活性.
在发育/功能基因和生物标志物 (BUN,CR,NAG) 中检测到异常.
阿斯塔山丁部分缓解了素诱导的损伤.

结论:

科尔奇辛在斑马鱼中诱导发育缺陷和毒性,主要是通过调节氧化应激.
斑马鱼作为一个有价值的模型来研究菌素的毒性.
阿斯塔克桑丁显示出作为治疗剂的潜力,可以对抗素诱导的损伤.

关键词:

科尔奇辛 (Colchicine) 是一种可口药.发展性毒性发展性毒性氧化应激是一种氧化应激.致毒性致毒性斑马鱼是一种斑马鱼.

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