双边卵巢切除术的心血管结果:一个系统的审查和元分析
Tanawat Attachaipanich1, Suthinee Attachaipanich2, Kotchakorn Kaewboot3
1Department of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, 64110, MO, USA.
Indian heart journal
|August 14, 2025
概括
双边卵巢切除术会增加心血管疾病 (CVD) 的风险,尤其是在更年期前进行时. 这种手术程序与年轻女性心力衰竭和冠状动脉疾病的风险更高有关.
科学领域:
- 心血管科学 心血管科学
- 生殖内分泌学 生殖内分泌学
- 手术结果研究研究.
背景情况:
- 心血管疾病 (CVD) 的风险在绝经后在女性中升级.
- 双边卵巢切除术对心血管 (CV) 结果的影响需要澄清.
- 这项研究研究了双边卵巢切除术与心血管结局之间的关联.
研究的目的:
- 为了评估经过双边卵巢切除术的妇女的心血管结果.
- 为了确定双边卵巢切除术是否会影响心血管事件的风险.
- 评估手术时的年龄对这些心血管风险的影响.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane CENTRAL进行了系统的文献搜索.
- 包括的研究比较了双边卵巢切除术和没有双边卵巢切除术的女性的CV结果.
- 分析利用了一个随机效应模型,对来自18项研究的数据 (2,414,600名参与者) 进行分析.
主要成果:
- 双边卵巢切除显示心血管疾病风险略有增加 (HR 1.05) 和心力衰竭风险更高 (HR 2.25).
- 绝经前双侧卵巢切除与心血管疾病 (HR 1.15) 和冠状动脉疾病 (HR 1.26) 的风险增加有关.
- 绝经后双边卵巢切除并没有显示出心血管事件的风险增加.
结论:
- 双边卵巢切除术与心血管事件风险增加有关,特别是在绝经前进行时.
- 这些发现强调了手术时的年龄在评估卵巢切除术后心血管风险时的重要性.
- 需要进一步研究预防策略和受影响妇女的风险分层.
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