相关实验视频
Updated: Sep 11, 2025

07:07
Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
Published on: January 7, 2019
6.2K
臭氧作为温度-eGFR关联中的调解剂和效果修饰剂:对健康检查队列的纵向研究
Zhongguo Huang1, Jinlu Lu2, Guanhao He3
1Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China; Department of Environmental Health Sciences, College of Integrated Health Sciences, University at Albany, The State University of New York, Rensselaer, NY, USA.
Environmental research
|August 14, 2025
概括
高温和臭氧 (O3) 污染显著降低了功能,通过估计的膜过率 (eGFR) 来衡量. 臭氧既起调解作用又起修饰作用,加剧了热对脏健康的负面影响.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 功能容易受到环境因素的影响.
- 环境温度和臭氧 (O3) 对功能的综合影响,特别是估计的膜过率 (eGFR),尚未完全理解.
- 臭氧在调节温度对脏健康的影响中的作用需要进行系统的研究.
研究的目的:
- 调查臭氧 (O3) 对温度和估计膜过率 (eGFR) 之间的关联的修饰和调解作用.
- 量化温度和O3对功能的联合影响.
- 确定脆弱人群并了解热量和O3暴露对脏健康的影响之间的相互作用动态.
主要方法:
- 利用了济南大学第一附属医院26,244名患者的数据.
- 采用了通用线性混合模型来分析O3对温度-eGFR关系的介导和相互作用效应.
- 应用基于量子的g计算来估计温度和O3对eGFR的联合影响.
主要成果:
- 温度升高和O3独立地与降低的EGFR相关.
- 温度和O3的四分位数间范围 (IQR) 增加导致eGFR显著下降.
- 高温高O3事件显示出低eGFR的最大相对风险,表明了协同效应. 臭氧约占总影响的20.56%.
结论:
- 环境温度和臭氧 (O3) 暴露都会对功能产生不利影响,导致EGFR降低.
- 臭氧作为一个重要的调解剂和修饰剂,放大了高温对脏健康的有害影响.
- 经历功能快速下降的个体对这些环境暴露特别脆弱.
相关概念视频
Effect of Temperature Change on Reaction Rate
4.3K
The Arrhenius equation,
4.3K
Hess's Law
46.2K
There are two ways to determine the amount of heat involved in a chemical change: measure it experimentally, or calculate it from other experimentally determined enthalpy changes. Some reactions are difficult, if not impossible, to investigate and make accurate measurements for experimentally. And even when a reaction is not hard to perform or measure, it is convenient to be able to determine the heat involved in a reaction without having to perform an experiment.
46.2K
Regulation of Angiogenesis and Blood Supply
2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
Effects of Temperature on Free Energy
26.0K
The spontaneity of a process depends upon the temperature of the system. Phase transitions, for example, will proceed spontaneously in one direction or the other depending upon the temperature of the substance in question. Likewise, some chemical reactions can also exhibit temperature-dependent spontaneities. To illustrate this concept, the equation relating free energy change to the enthalpy and entropy changes for the process is considered:
26.0K
Oxidative Cleavage of Alkenes: Ozonolysis
11.1K
In ozonolysis, ozone is used to cleave a carbon–carbon double bond to form aldehydes and ketones, or carboxylic acids, depending on the work-up.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
11.1K
Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K

