成年早期的长期肥胖影响中年冠状动脉化发生率:一项25年纵向研究
Shunyi Li1,2, Haobin Zhou3, Wenyan Li1,2
1State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
European heart journal. Cardiovascular Imaging
|August 14, 2025
概括
从年轻成人开始对身体圆度指数 (BRI) 的纵向暴露与中年冠状动脉化 (CAC) 风险增加有关. 更高的累积BRI (cBRI) 也与更高的全因死亡风险相关.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 生物识别信息 生物识别信息
背景情况:
- 冠状动脉化 (CAC) 是心血管疾病的重要指标.
- 评估纵向脂肪性暴露可能为CAC风险提供见解.
- 身体圆度指数 (BRI) 是衡量脂肪分布的指标.
研究的目的:
- 评估从年轻成人开始用BRI测量纵向脂肪暴露与中年CAC发病率之间的关联.
- 为了确定累积BRI (cBRI) 是否是CAC发病率的预测指标.
- 探索cBRI与全因死亡率之间的关系.
主要方法:
- 在25年内利用了2102名参与CARDIA研究的数据.
- 在25年使用心脏计算机断层扫描评估CAC发病率.
- 计算了累积BRI (cBRI) 并使用后勤回归和受限立方线 (RCS) 分析分析了其与CAC的关联.
主要成果:
- 较高的cBRI与增加CAC发病率的风险显著相关.
- 在cBRI最高四分之一的参与者对CAC的赔率比为2.52.
- RCS分析表明cBRI和CAC风险之间存在线性关系,较高的cBRI与全因死亡率的增加有关.
结论:
- 从成年早期开始增加的累积身体圆度指数 (cBRI) 与中年冠状动脉化 (CAC) 的风险增加有关.
- BRI可以作为一种有价值的标志物,用于识别高风险的个人CAC.
- 使用BRI进行纵向脂肪性评估可以提高心血管风险预测.
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