在针对性免疫疗法治疗固体瘤之前,图像导向和抗体向的联合α-疗法
Maciej Kujawski1, Eric Aniogo1, Patty Wong2
1Department of Immunology and Theranostics, Beckman Research Institute, City of Hope, Duarte, California.
概括
三重向治疗,结合图像导向放射治疗 (IGRT),向α疗法 (TAT) 和免疫细胞因子治疗,在固体瘤中实现了完全治愈. 这种组合还在重新挑战时诱导瘤排斥,显示出强大的抗瘤免疫力.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 辐射瘤学 辐射瘤学
背景情况:
- 固体瘤是一个重大的治疗挑战.
- 向治疗有可能提高疗效和降低毒性.
- 结合不同的向模式可以提高治疗结果.
研究的目的:
- 评估图像导向辐射疗法 (IGRT),低剂量向阿尔法疗法 (TAT) 和针对固体瘤的抗体向互白素-2免疫细胞因子治疗的疗效.
- 为了确定是否结合两个向辐射疗法比单一治疗和免疫细胞因子治疗更有效.
- 为了优化剂量和瘤模型,用于三重组合治疗.
主要方法:
- 转基因动物的同源性乳腺和结肠瘤用IGRT (单剂或分剂) 和低剂量TAT (225Ac-DOTA-anti-CEA) 治疗.
- 剂量和瘤模型被优化为IGRT,TAT和免疫细胞因子治疗的组合.
- 进行了免疫类型鉴定,以评估免疫细胞和瘤微环境的变化.
主要成果:
- 分割IGRT在乳腺癌模型中显示出比单剂量IGRT更好的抗体透.
- 与低剂量TAT结合的IGRT导致优异的瘤回归和存活率.
- 在结肠癌模型中,三重疗法 (分离IGRT + TAT + 免疫细胞因子) 导致完全治愈和拒绝复发.
- 三重疗法显著增加了自然杀手和CD8+T细胞,调节了瘤微环境,并增强了T细胞记忆表型.
结论:
- 三重向治疗在固体瘤模型中表现出卓越的治疗效果.
- 通过三重组合,观察到完全治愈瘤和拒绝瘤复发.
- 免疫类型鉴定证实了通过三重疗法显著的免疫系统激活和瘤微环境的调节.
更多相关视频
10:47Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
Published on: February 3, 2015
8.9K
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
12.3K
相关概念视频
01:27Tumor Immunotherapy
660
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
660
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K