接种HPV疫苗可以改善患有呼吸道 papilomatosis的儿童的免疫反应
Miguel A Prieto-Islas1,2, Esmeralda Godoy-Dahbura3, Diana C Villalpando-Sánchez1,4
1Immunometabolism Laboratory; Epidemiology, Endocrinology & Nutrition Research Unit, Mexico Children's Hospital, 162 Dr. Marquez, Mexico City, 06720, Mexico.
Scientific reports
|August 14, 2025
概括
在患有复发性呼吸道乳头瘤 (RRP) 的儿童中,人类乳头瘤病毒 (HPV) 疫苗接种提高了抗体水平,并改变了免疫反应. 这种辅助疗法减少了病毒载量和切除乳头瘤的手术需求.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿科 儿科 儿科
背景情况:
- 复发性呼吸道乳头瘤 (RRP) 是一种罕见的气道瘤,由低风险的人类乳头瘤病毒 (HPV) 类型6和11引起.
- 手术切除是RRP的主要治疗方法,但复发很常见,需要有效的辅助疗法.
- 作为儿科RRP的辅助治疗,HPV疫苗的作用,特别是其免疫效应,仍未得到充分研究.
研究的目的:
- 评估HPV疫苗作为儿科RRP辅助疗法的疗效.
- 评估儿童RRP患者接种HPV疫苗后的免疫变化,包括抗体标位和细胞因子概况.
- 为了将观察到的免疫学转变与临床结果相关联,例如病毒载量和手术复发率.
主要方法:
- 在完成HPV疫苗接种计划之前和6个月后,从10名儿科RRP患者收集了血液和喉活检样本.
- 使用qPCR量化HPV 6/11病毒载量.
- 用ELISA测量了针对HPV L1蛋白的血清抗体标位 (IgG,IgM),并分析了细胞因子 (IL-10,TNFα) 概况.
主要成果:
- 接种HPV疫苗导致HPV 6/11在乳头瘤组织中的病毒载量显著下降.
- 观察到血清IgG抗体对抗HPV L1蛋白的显著增加,而IgM水平保持不变.
- 接种疫苗引发了转向Th1-介导免疫反应的转变,其特点是组织中免疫抑制IL-10的减少和血清中炎症促TNFα的增加.
结论:
- 在儿科RRP患者中,辅助性HPV疫苗接种增强了抗HPVIgG抗体的产生,并促进了促炎系统性免疫反应.
- 观察到的免疫变化与病毒载荷的减少和手术干预频率的减少有关.
- HPV 疫苗接种显示出作为有效的辅助疗法,用于管理儿科复发性呼吸道乳头炎的承诺.
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