相关实验视频

Updated: Sep 11, 2025

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

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FANTASIA利用语言模型来解码跨越动物生命树的功能性暗色蛋白质组

Gemma I Martínez-Redondo1,2, Francisco M Perez-Canales3, Belén Carbonetto4

  • 1Metazoa Phylogenomics and Genome Evolution Lab, Institute of Evolutionary Biology (CSIC-UPF), Barcelona, Spain. gemma.martinez@ibe.upf-csic.es.

Communications biology
|August 15, 2025
PubMed
概括

使用蛋白质语言模型的新工具FANTASIA为大多数蛋白质提供了功能注释,即使是传统方法错过的蛋白质. 这促进了对基因功能的理解,特别是在非模型生物中.

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相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Conservation of Protein Domains Over Different Proteins02:26

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A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Ribosome Profiling02:24

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Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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