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健康成年人肠道微生物群组成和心脏代谢参数之间的关联

Seyda Silan Okalin^1,2, Nazli Arslan², Ebru Demiray Gürbüz²

¹BioIzmir - Izmir Health Technologies Development and Accelerator Research and Application Center, Dokuz Eylul University, Izmir, Türkiye.

BMC microbiology

|August 15, 2025

概括

这项研究揭示了与土耳其成年人的代谢健康相关的特定肠道细菌. 某些细菌系与体重指数 (BMI) 和血液标志物相关,突出了特定区域的肠道微生物组作用.

科学领域:

微生物学微生物学
人类肠道微生物组
代谢健康代谢健康

背景情况:

人体肠道微生物群,包括数万亿个细胞,通过代谢产生的代谢物产生影响健康.
微生物群的组成受到地理,饮食和遗传学的影响.
肠道失调 (不平衡) 与代谢疾病有关.

研究的目的:

来自土耳其伊兹米尔省的健康成年人肠道微生物群组成的特征.
评估肠道微生物组成和心脏代谢参数之间的关联.

主要方法:

招募18岁以上的成年人,居住在伊兹密尔省.
收集了便和血液样本进行分析.
进行了16S rRNA基因测序 (牛津纳米孔) 以进行分类学分类,并使用Epi2Me分析了主导属;评估了血液代谢标记物和统计学检查的关联.

主要成果:

确定了Segatella (Prevotella) copri作为占主导地位的物种 (51%).
在BMI组之间发现了Shannon指数和Firmicutes/Bacteroidetes比率的变化.
在Lachnospira/Ruminococcus属和BMI之间观察到显著的负相关性;Lachnospira的丰度下降与更高的HbA1c;Vescimonas的丰度预测HOMA-IR;Ruthenibacterium的丰度增加与更高的HDL水平.

结论:

这个群体中占主导地位的肠道细菌分类与其他报告的个人资料有所不同,这表明了特定区域的微生物特征.
特定的肠道微生物属与关键代谢健康指标 (BMI,HbA1c,HOMA-IR,HDL) 有显著的关联.
这些发现突显了肠道微生物群在代谢调节中的作用,并强调了土耳其需要进行特定区域的研究.

关键词:

心脏代谢参数的心脏代谢参数我们的肠道微生物群.健康的成年个人健康的成年人.牛津纳米孔测序的测序

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