细菌性阴道炎相关微生物群和Trichomonas vaginalis之间的相互作用调节了寄生虫诱导的致病性和宿主免疫反应
Shu-Fang Chiu1,2,3, Ching-Yun Huang1,2, Chien-Yung Chen3
1Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei City, 114, Taiwan.
Parasites & vectors
|August 15, 2025
概括
像Prevotella bivia和Trichomonas vaginalis (Tv) 这样的阴道细菌之间的相互作用增加了Tv的致病性和宿主炎症. 这项研究强调了阴道微生物组在性传播感染中的作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 妇科 妇科医生 妇科
背景情况:
- 由Trichomonas vaginalis (Tv) 引起的三菌是一种常见的非病毒性性传播感染 (STI).
- 细菌性阴道炎 (BV) 涉及有益的乳酸菌的减少和厌氧细菌的过度生长.
- 无论是BV相关细菌 (BVB) 还是Tv都与负面的妇科结果有关.
研究的目的:
- 研究阴道细菌与TV之间的相互作用如何影响TV的致病性.
- 为了确定这些相互作用对TV诱导的主体免疫反应的影响.
主要方法:
- 一个共同培养系统被用来研究tv的相互作用与乳杆菌crispatus,大肠杆菌,Prevotellabivia和乳杆菌iners在宫外细胞 (Ect1).
- 在TV-细菌相互作用后评估了TV的粘附性,细胞毒性和细胞因子分泌.
- 研究了宿主炎症的分子机制,包括信号通路和上皮-介质细胞过渡 (EMT).
主要成果:
- 普雷沃特拉生物显著增强了tv ap65基因表达和tv对宿主细胞的粘附.
- 预暴露于P. bivia的tv增加了细胞毒性,并提高了Ect1细胞中IL-6,IL-8,CXCL1和IP-10分泌的调节.
- 生物刺激激活PI3K,ERK和p38MAPK通路,诱导宿主细胞中的EMT.
结论:
- 特定的BVB,如P. bivia,可以增强TV的病原性.
- 阴道微生物组在Tv感染期间显著影响宿主细胞反应.
- 这项研究促进了对阴道生态系统中宿主-细菌-寄生虫相互作用的理解.
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