在治疗稳定支气管炎症时,Qingbu Weijing的有效性和安全性:多中心,双盲,随机和安慰剂对照试验的研究方案
Jin-Zhi Zhang1, Sha-Sha Yuan1, Zhi-Shen Ruan1
1Respiratory department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
BMC complementary medicine and therapies
|August 15, 2025
概括
这项研究研究了青微精液 (QWD) 对于具有粘液过分分泌的稳定支气管切开症. QWD可以减少恶化和改善症状,提供一种潜在的传统中医疗治疗.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 支气管病是一种慢性呼吸道疾病,其特点是持续咳,过度吐和反复感染.
- 气道粘液过分分泌是一个关键特征,导致频繁的急性恶化和降低生活质量.
- 青布威济 (QWD) 显示出改善吐产生的潜力,并减少支气管炎症的炎症.
研究的目的:
- 评估QWD在患有稳定支气管切除和气道粘液过分分泌的患者中的安全性和有效性.
- 评估QWD对急性恶化,唾液体积,肺功能和生活质量的影响.
- 通过分析粘素水平,呼吸道菌群和炎症标志物来探索QWD的潜在机制.
主要方法:
- 一个前性,随机,双盲,安慰剂控制的多中心试验,涉及108名患者.
- 参与者被分配到QWD或安慰剂在2:1的比率24周,随后是24周的随访.
- 主要结局:急性恶化次数;次要结局:唾液体积,肺功能,生活质量,粘素水平,呼吸道菌群和炎症标志物.
主要成果:
- 这一部分应在试验结果可用后填写.
结论:
- 该试验将确定QWD的临床疗效,安全性和稳定支气管切除症的机制.
- 结果可能支持将传统中医 (TCM) 整合到支气管病的管理中.
- 需要进一步的研究来证实QWD在改善患者结果中的作用.
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