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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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在患有末期脏疾病和慢性炎症的个体中,血液透析后依赖流动的肝功能障碍
Oscar Swift1,2, Bobby V M Dasari3, Malcolm A Finkelman4
1School of Life and Medical Science, University of Hertfordshire, Hatfield, Hertfordshire, UK.
概括
患有慢性炎症的血液透析患者表现出肝功能受损和肠道透性增加. 这表明,肝脏减少清除毒素的能力有助于这些患者持续的炎症.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
背景情况:
- 肝脏排毒肠道衍生物质,防止它们的全身循环.
- 慢性炎症在血液透析患者中很普遍,可能与增加肠道通透性有关.
- 这项研究调查了慢性炎症的血液透析患者的肝功能.
研究的目的:
- 评估血液循环依赖的肝功能是否受损于血液透析患者的慢性炎症.
- 探索肝功能,肠道透性和炎症标志物之间的关系.
主要方法:
- 50名血液透析患者被分为炎症 (中位数hs-CRP≥5 mg/dL) 和非炎症组.
- 依赖流量的肝功能是用红氨酸绿色清除后的血液透析来测量的.
- 血清β-D-葡萄糖水平被评估为肠道透性的标志物.
主要成果:
- 炎症组表现出减少的绿色氨酸血消失率和更高的绿色氨酸保留率.
- 血液透析后的β-D-葡萄糖水平在炎症组显著更高.
- 印ocyanine绿色保留和血液透析后β-D-葡萄糖独立预测了hs-CRP水平.
结论:
- 血液透析患者患有不明原因的炎症,肝功能受损,肠道通透性增加.
- 肠道毒素的肝脏清除受损可能会在这个人群中传播慢性炎症.
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