皮肤学模仿帕杰特乳腺疾病:一个系统的审查
Emily Volfson1, Michal Moshkovich1, Rebeca Yakubov2
1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Journal of cutaneous medicine and surgery
|August 15, 2025
概括
乳腺帕杰特病 (MPD) 是一种罕见的乳腺癌,通常被误诊为良性疾病或黑色素瘤. 早期活检对于及时诊断和治疗至关重要,因为延迟会对患者的结果产生重大影响.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 乳腺帕杰特病 (MPD) 是一种罕见的乳腺恶性瘤 (1-4%的病例).
- MPD经常表现出模仿良性皮肤病或黑色素瘤的症状,导致诊断挑战.
- 它经常与潜在的管道癌 in situ 或侵入性管道癌相关.
研究的目的:
- 审查乳腺帕杰特病的诊断挑战和错误诊断模式.
- 探索延迟识别和治疗MPD的后果.
- 突出早期诊断和适当的管理策略的重要性.
主要方法:
- 对Embase和MEDLINE数据库的系统文献审查.
- 包括29项研究报告了32例MPD初始误诊的病例.
- 对病变特征,诊断延迟和治疗结果的分析.
主要成果:
- 所有审查的MPD病例 (32) 最初被误诊,最常见的是黑色素瘤 (44.4%) 和亚托邦性皮炎 (25.0%).
- 平均诊断延迟为2.3年;病变通常是单边的 (93.8%) 并涉及乳头 - 乳头复合体 (87.5%).
- 图像显示敏感性有限;活检是必不可少的. 手术是主要治疗方法 (75%),在1.3年的随访期间没有报告复发.
结论:
- 较高的临床怀疑和较早的组织采样对于减少MPD误诊至关重要.
- 需要标准化的诊断途径来改善患者的治疗结果.
- 及时诊断和手术干预是有效的管理乳腺帕杰特病.
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