![Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F63025.jpg&w=3840&q=50)
[18F]FMeNER-D2的自动放射合成使用简化的一法18F-甲基化方法
Kazunori Kawamura1, Wakana Mori1, Yusuke Kurihara1,2
1Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, Japan.
Journal of labelled compounds & radiopharmaceuticals
|August 15, 2025
概括
我们开发了一种简化的一方法来合成[18F]FMeNER-D2,它是用于大脑北上腺素输送器成像的放射追踪器. 这种自动化放射合成提高了正电子发射断层扫描 (PET) 应用的效率.
科学领域:
- 放射化学 放射化学是指辐射化学.
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 上腺素载体 (NET) 成像对于理解神经系统疾病至关重要.
- [18F]FMeNER-D2是一种用于NET成像的PET射线追踪器.
- [18F]FMeNER-D2的传统放射合成是复杂的,需要一个两自动化系统.
研究的目的:
- 为了简化和优化[18F]FMeNER-D2.2的自动化放射合成.
- 为[18F]FMeNER-D2生产开发一种更有效的单方法.
- 为了提高这种PET标记器的可访问性,用于研究和临床应用.
主要方法:
- 开发了一种使用[18F]甲基-d2-酸盐作为化剂的单放射合成策略.
- 使用了一个完全自动化的18F标签合成器,配备了一个单单元.
- 优化反应条件,以O-甲基化诺乙烯基复boxetine (NER).
主要成果:
- 合成时间达到66±4.7分钟.
- 获得了9.0 ± 0.8% (n=3) 的放射性化学产量.
- 报告的摩尔活性为130-275GBq/μmol,放射化学纯度>97%.
结论:
- 成功开发了一种简化,单,完全自动化的[18F]FMeNER-D2.2的放射合成.
- 新方法避免了[18F]化物的预干燥,简化了该过程.
- 这种改进的合成促进了[18F]FMeNER-D2的使用,用于PET成像对北上腺素载体的成像.
![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)
![Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F55537.jpg&w=3840&q=50)
相关概念视频
01:16Other Nuclides: 31P, 19F, 15N NMR
465
Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a...
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a...
465
01:13Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
6.4K
Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
6.4K