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用teprotumumab治疗的患者的耳部症状:一个多机构的国家队列研究

Kaitlin Hori¹, Talia Wenger¹, Shaili Davuluru¹

¹Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

The Laryngoscope

|August 15, 2025

概括

甲状腺眼病 (TED) 的teprotumumab治疗与听力损失和耳风险的增加有关. 治疗Teprotumumab的患者需要对这些潜在的耳部病理副作用进行监测.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

2020年批准的一种单克隆抗体Teprotumumab治疗甲状腺眼病 (TED).
潜在的不良影响包括耳管和欧斯塔基管脂肪的问题.
德鲁马布与耳部病的不良事件之间的关联需要进行调查.

研究的目的:

为了调查TED患者治疗Teprotumumab的感觉神经听力损失 (SNHL) 和耳的发生率.
为了确定与不使用相比,与Teprotumumab使用相关的SNHL和耳发病的几率.

主要方法:

一项使用TrinetX多机构数据库的回顾性队列研究.
倾向性得分匹配被用来比较那些接受Teprotumumab的TED患者与那些没有接受Teprotumumab的TED患者.
使用ICD-10代码确定了结果 (SNHL和耳);计算了几率比率.

主要成果:

与非Teprotumumab队列 (n=947) 相比,Teprotumumab队列 (n=947) 显示SNHL (10.0%对3.7%) 和耳 (5.6%对1.8%) 的发病率明显更高.
使用teprotumumab与SNHL (OR,2.89) 和耳 (OR,3.13) 的几率增加有关.
两个匹配组的平均随访时间大约为27-29个月.

结论:

采用teprotumumab与TED患者SNHL和耳的发展有显著的相关性.
对于接受teprotumumab的患者来说,监测耳部不良事件至关重要,以防止潜在的不可逆转损伤.
需要进一步的研究来建立标准化的监测和治疗调整协议.

关键词:

不良事件不良事件不良事件听力损失听力损失是什么耳毒性耳毒性耳毒性这就是为什么teprotumumab.耳声 (tinnitus) 是一种耳声.

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