检查炎症是否介导遗传风险和创伤对精神病理学的影响
Philippa Lilford1,2,3, Gemma Hammerton1,4, Golam M Khandaker1,2,4
1Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
BJPsych open
|August 15, 2025
概括
儿童时期的炎症并没有介绍遗传风险或创伤与成人精神病理学之间的联系. 为了制定有效的治疗策略,需要对其他途径进行进一步的研究.
科学领域:
- 精神病学和发育心理学.
- 遗传学和分子生物学
- 免疫学和炎症研究研究
背景情况:
- 纵向研究表明,童年炎症标志物,创伤和成人精神病理之间存在联系.
- 遗传倾向和早期生命创伤是已知的心理健康状况的风险因素.
研究的目的:
- 调查童年炎症是否在遗传风险,创伤暴露和成年早期精神病理的发展之间起到调解作用.
- 分析炎症标记物 (C-反应蛋白,互白素-6) 在遗传责任,童年创伤和成人精神病结局之间的关系中的调解作用.
主要方法:
- 利用了来自阿文长度研究的父母和儿童 (ALSPAC) 的数据.
- 评估了创伤暴露 (5-11岁),炎症标志物 (C反应蛋白,9岁的互白素-6) 和精神病理 (抑郁,焦虑,负面症状,24岁的精神病体验).
- 针对主要精神疾病使用多基因风险评分 (PRS) 并对假定数据进行调解分析 (N=7859-8700).
主要成果:
- 大多数精神病学PRS与成人精神病理学有关,除了精神病体验的PRS外.
- 童年创伤与所有测量的精神病理结果都有关联.
- 没有发现有意义的证据表明炎症中介于遗传风险,创伤和精神病理之间的关系.
结论:
- 儿童时期的互白素-6和C-反应蛋白水平似乎没有调解从遗传责任或创伤到成人精神病理学的途径.
- 需要进一步的纵向研究来探索其他炎症和非炎症途径.
- 识别可修改的新型目标对于开发因遗传或创伤相关因素而面临精神疾病风险的个体的有效治疗至关重要.
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