白物质中的尾部和胸部分离 脑网络社区 患有阿尔茨海默氏症的人口
Frederick Xu1, Duy Duong-Tran2, Yize Zhao3
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics
|August 15, 2025
概括
阿尔茨海默病 (AD) 破坏大脑网络,造成白质损伤. 在阿尔茨海默氏症患者中,大脑网络分裂,揭示了一个与体和尾部区域变化相关的独特的第七个社区,表明了断开综合征.
科学领域:
- 神经成像是一种神经成像.
- 神经解剖学是一个神经解剖学.
- 大脑网络 大脑网络
背景情况:
- 阿尔茨海默病 (AD) 与灰色和白质神经解剖学变化有关.
- 阿尔茨海默病和白质恶化之间的系统关系尚未完全理解.
研究的目的:
- 为了研究阿尔茨海默病和白质解剖学恶化之间的系统关系.
- 为了确定AD的新型白质生物标志物.
主要方法:
- 从扩散张力成像 (DTI) 数据构建结构性大脑网络.
- 网络使用有趣的大脑区域 (ROI) 作为节点,白质连接作为纤维密度加权的边缘.
- 应用共识模块化优化来分析健康对照组 (HC),轻度认知障碍 (MCI) 和AD受试者的社区结构.
主要成果:
- 在AD组的大脑网络分区中,在1.3的分辨率参数 (γ) 上出现了一个独特的第7个共识社区.
- 这个社区代表了基于奖励的决策模块的分裂,在HC或MCI组中没有观察到.
- 在AD大脑网络中,发现了thalamic和caudal区域在AD大脑网络中的分离增加.
结论:
- 阿尔茨海默病可能表现为在中视层结构层面上的断开综合征.
- 在AD网络中,thalamic和caudal区域的分离是一个新的发现,对理解认知缺陷有意义.
- 这项研究为在AD神经关联中探索丘陵体和尾状体开辟了新的途径.
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