基于乳酸菌的益生菌尾酒通过改变肠道代谢来抑制结肠炎相关的癌症
Weiyi Wang1, Ying Xu1, Yimin Chu1
1Department of Endoscopy, Shanghai Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, PR China.
International journal of clinical and experimental pathology
|August 15, 2025
概括
基于乳酸菌的益生菌尾酒通过改变肠道代谢物和基因表达来预防结肠直肠癌. 这种干预通过调节关键代谢途径和微生物组成来减少炎症和瘤形成.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 肠道失调是结直肠癌 (CRC) 发展的关键因素.
- 乳杆菌益生菌可以通过解决失生症来减轻结肠炎相关的癌症 (CAC).
- 乳杆菌益生菌对CAC的代谢影响尚未完全理解.
研究的目的:
- 为了研究基于乳酸菌的益生菌尾酒对CAC的保护作用.
- 阐明益生菌改变肠道新陈代谢和CAC中的基因表达的机制.
- 分析肠道微生物群,宿主代谢和瘤发生之间的相互作用.
主要方法:
- 诱导CAC的阿佐西米/德克斯硫酸 (AOM/DSS) 的小鼠模型.
- 使用基于乳酸菌的益生菌尾酒进行预处理.
- 对结肠炎症,瘤发生,肠道微生物群组成和宿主基因表达的分析.
- 代谢和转录组分析的比较.
主要成果:
- 益生菌预处理显著减少了肠道炎症和瘤负担.
- 基因表达转向抑制癌症,对瘤基因进行下调和对瘤抑制基因进行上调.
- 微生物群分析显示,乳酸菌增加,致病细菌减少.
- 代谢分析发现了37个代谢途径的变化,其中5个途径 (氨酸/氨酸,氨酸,氨酸,氨酸,氨酸代谢) 受到Lactobacillus的显著影响.
结论:
- 基于乳酸菌的益生菌通过调节肠道代谢物提供对CAC的保护.
- 益生菌尾酒影响宿主基因表达,影响瘤基因和瘤抑制基因.
- 受到Lactobacillus影响的特定代谢途径对于益生菌的抗炎和抗瘤作用至关重要.
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